When administering IV fluids for a dental sedation case, it is important to account for baseline maintenance needs, preoperative fluid deficits (due to NPO status), and ongoing losses.
-  Maintenance IV Fluid Rate Calculation
 
A commonly used formula for calculating maintenance IV fluid rates in adults is based on the 4-2-1 rule:
- 4 mL/kg/hr for the first 10 kg
 
- 2 mL/kg/hr for the next 10 kg
 
- 1 mL/kg/hr for each additional kg over 20 kg
 
Example Calculation for a 70 kg Patient
- First 10 kg → 4 × 10 = 40 mL/hr
 
- Next 10 kg → 2 × 10 = 20 mL/hr
 
- Remaining 50 kg → 1 × 50 = 50 mL/hr
Total maintenance fluid rate = 110 mL/hr 
-  Fluid Deficit Due to NPO for 8 Hours
 
To estimate the fluid deficit, multiply the hourly maintenance rate by the duration of NPO:
- Deficit = Maintenance Rate × NPO Hours
 
- Example for a 70 kg patient:
- 110 mL/hr × 8 hrs = 880 mL fluid deficit
 
 
This deficit should be replaced over the first few hours of the procedure:
- 50% in the first hour
 
- 25% in the second hour
 
- 25% in the third hour
 
-  Total IV Fluid Rate During the Procedure
 
The total fluid rate should combine maintenance fluids + NPO replacement as follows:
- First Hour: (110 mL/hr maintenance) + (440 mL deficit replacement) = 550 mL/hr
 
- Second Hour: (110 mL/hr maintenance) + (220 mL deficit replacement) = 330 mL/hr
 
- Third Hour: (110 mL/hr maintenance) + (220 mL deficit replacement) = 220 mL/hr
 
- Beyond 3rd Hour: Maintain 110 mL/hr if no additional fluid loss occurs
 
-  Fluid Choice
 
- Balanced crystalloids (e.g., Lactated Ringer’s (LR) or Plasma-Lyte) are preferred over 0.9% Normal Saline (NS) to reduce the risk of metabolic acidosis.
 
- Dextrose-containing fluids (e.g., D5LR or D5NS) may be considered in pediatric cases to prevent hypoglycemia.
 
-  Adjustments Based on Patient Needs
 
- Hypovolemia or Hypotension: Increase fluid rate or give boluses of 250-500 mL LR or NS as needed.
 
- Cardiac or Renal Disease: Avoid fluid overload—consider reduced rates and titrate carefully.
 
| 
 Step 
 | 
 Calculation for a 70 kg Patient 
 | 
| 
 Maintenance Rate 
 | 
 110 mL/hr 
 | 
| 
 NPO Deficit (8 hrs) 
 | 
 880 mL 
 | 
| 
 Fluid Replacement Schedule 
 | 
 550 mL/hr (1st hr), 330 mL/hr (2nd hr), 220 mL/hr (3rd hr) 
 | 
| 
 After Deficit is Replaced 
 | 
 110 mL/hr 
 | 
 

CLINICAL PEARL: 
Know how to run your fluids and why. Keeping a patient properly hydrated will avoid cardiovascular problems and diminish post sedation nausea and vomiting!